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ACT Laboratory

Our Focus

The ACT Lab's core research areas include:

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  • Cellular Ageing and Stem Cell Biology: Unravelling the molecular mechanisms driving stem cell exhaustion and dysfunction during ageing

  • RNA-Based Therapeutics: Developing miRNA-based interventions for regenerative medicine, particularly targeting cardiovascular and musculoskeletal systems

  • Extracellular Vesicle Biology: Utilizing EVs as a source of biomarkers in diverse age-related conditions, and for the delivery of functional molecules to enhance tissue repair and regeneration

Our Work

The ACT Lab is dedicated to tackling significant health challenges in regenerative medicine, with a primary focus on improving outcomes in wound healing, bone regeneration, and metabolic diseases. To achieve this, we employ a multifaceted approach that integrates cutting-edge technologies and fundamental biological principles.

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We employ advanced cellular models that faithfully mimic the complexity of target tissues and organs in vitro to facilitate detailed mechanistic investigations into the cellular and molecular determinants underlying both normal tissue homeostasis and disease pathogenesis.

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Leveraging high-throughput screening (HTS) technologies, we systematically investigate the potential of small molecules and microRNAs (miRNAs) to identify novel therapeutic targets that can modulate cellular behavior and promote regeneration.

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Furthermore, we are actively exploring the versatile role of extracellular vesicles (EVs). We investigate their potential as a rich source of biomarkers for early disease detection and monitoring, as well as their utility as sophisticated drug delivery systems to precisely target therapeutic molecules to sites of injury or disease.

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Our overarching goal is to develop innovative technologies that can enhance regeneration specifically in challenging contexts such as aged or metabolically compromised settings. By bridging fundamental discoveries with translational applications, we aim to create effective regenerative therapies that improve the health and well-being of individuals facing these debilitating conditions.

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